Maud Fagny

Maud Fagny

Postdoctoral Fellow

UMR7206 Eco-Anthropologie

Biography

My research is focused on understanding the regulation of the expression of polygenic traits at the molecular level, and their evolution. I recently received a Marie Skłodowska Curie Individual Fellowship to study polygenic adaptation targeting gene expression regulation using eQTL Networks.

  • Population Genomics
  • Polygenic Adaptation
  • Epigenomics
  • Transcriptomics
  • Systems Biology
  • Gene Regulatory Networks
  • Biostatistics

  • PhD in Population Genomics and Epigenomics, 2015

    Institut Pasteur / Université Pierre et Marie Curie

  • Master in Biosciences, 2011

    École normale supérieure de Lyon

  • Licence in Fundamental biology, 2009

    École normale supérieure de Lyon

Projects

PATTERNS

Polygenic adaptation, in which small changes in allele frequencies co-occur at multiple variants, has been proposed to be a major adaptive mechanism for polygenic traits. Because 90% of genetic variants associated to polygenic traits are located in non-coding, regulatroy regions, I’m interested into studying the extent to which polygenic selection targets regulatory regions of the human genome. I propose to combine network biology and population genetics methods in order to develop a new approach to detect signatures of polygenic adaptation in regulatory regions.

Role of Enhancers in Maize Leaf Development Gene Regulatory Networks

This project aims at studying the role of transposable elements in the enhancer-mediated tissue-specific regulation of gene expression in maize tissues. I want to understand how transposable elements inserted in the neighborhood of genes have been shaping the tissue-specific gene regulatory networks. To this end, I use maize as a model, and I combine approaches from comparative genomics, systems biology and computational biology.

Previous projects

During my first postdoc, I investigated the genetic bases of the regulation of the expression of polygenic traits, using system biology approaches based on bipartite network representation. I notably characterized the regulatory role of germinal mutations increasing the risk to develop cancers.

PhD thesis - Genetic and epigenetic bases of human populations adaptation to the environment.

I did my PhD in population genomics and epigenomics. I studied the impact of the global environment on the genetic and epigenetic diversity of human populations. I investigated the role of a particular type of positive selection, selective sweeps, in shaping the human genome diversity. I also assessed the relative impact of genetic and environmental factors on the variation in DNA methylation profiles between human populations living in contrasted environements.

Experience

 
 
 
 
 

Post-doctoral Fellow

UMR7206 Eco-Anthropologie, MNHN, CNRS, Université de Paris, 75016 Paris, France

Apr 2020 – Present Paris, France
I investigate the extent of local polygenic selection targeting the regulation of gene expression in complex genomes by combining theoretical work and OMICS data analysis.
 
 
 
 
 

Post-doctoral Fellow

GQE - Le Moulon, Université Paris-Saclay, INRAE, CNRS, AgroParisTech, 91190, Gif-sur-Yvette, France

Jan 2019 – Mar 2020 Gif-sur-Yvette, France
I investigated the role of structural variations in non-coding regions in wiring the tissue-specific gene regulatory network of maize leaf during development using bipartite networks approaches.
 
 
 
 
 

Post-doctoral Fellow

LEE, CNRGH, CEA, 91000 Evry, France

Jan 2018 – Oct 2018 Gif-sur-Yvette, France Evry, France
I worked on the role of miRNAs in deregulating gene expression in the contexte of autoimmune diseases.
 
 
 
 
 

Post-doctoral Fellow

Department of Biostatistics, Harvard T.H. Chan School of Public Helath, Boston MA 02115, United States

Nov 2015 – Dec 2017 Gif-sur-Yvette, France
I characterized the regulatory role of non-coding mutations increasing the risk to develop cancer in humans using bipartite network approaches.
 
 
 
 
 

PhD student

Human Evolutionary Genetics, Institut Pasteur, CNRS UMR2000, Paris, France

Sep 2011 – Sep 2015 Paris, France
I investigated the impact of lifestyle and environment on the genetics and epigenetics variability of human genome.

Publications

Sexual dimorphism in gene expression and regulatory networks across human tissues
Differential DNA methylation in experienced meditators after an intensive day of mindfulness-based practice: Implications for immune-related pathways
PUMA: PANDA Using MicroRNA Associations
Nongenic cancer-risk SNPs affect oncogenes, tumour-suppressor genes, and immune function
Deregulation of microRNA expression in monocytes and CD4+ T lymphocytes from patients with axial spondyloarthritis

Contact

  • maud.fagny@mnhn.fr
  • EcoAnthropology Lab
    UMR 7206 CNRS/MNHN/Universite Paris Diderot
    Muséum National d'Histoire Naturelle
    Site du Musée de l'Homme
    Bureau E202
    17 place du Trocadéro
    75016 Paris
  • Unpredictable due to the post-coronavirus lockdown reopening.
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