Population Genomics

PATTERNS (2020 - 2021)

Polygenic adaptation, in which small changes in allele frequencies co-occur at multiple variants, has been proposed to be a major adaptive mechanism for polygenic traits. Because 90% of genetic variants associated to polygenic traits are located in non-coding, regulatory regions, I am interested in studying the extent to which polygenic selection targets regulatory regions of the human genome. I propose to combine network biology and population genetics methods in order to develop a new approach to detect signatures of polygenic adaptation in regulatory regions.

PhD thesis - Humans in an Adaptive World : Genetic and Epigenetic Responses to Environmental Challenges (2011-2015)

I did my PhD in population genomics and epigenomics. I studied the impact of the global environment on the genetic and epigenetic diversity of human populations. I investigated the role of a particular type of positive selection, selective sweeps, in shaping the human genome diversity. I also assessed the relative impact of genetic and environmental factors on the variation in DNA methylation profiles between human populations living in contrasted environments.